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Piramal Pharma Solutions, a leading global contract development and manufacturing organization (CDMO) and part of Piramal Pharma Ltd has launched a state-of-the-art spray drying suite at its peptide development and manufacturing facility in Turbhe, India. This strategic expansion enables PPS to address the complex formulation challenges associated with peptides and other complex molecules and support the growing demand for these innovative molecules.
Spray drying transforms liquid formulations into dry powders in a single step, enabling drug developers to enhance bioavailability, achieve precise particle size, and process sensitive compounds safely. This technique is especially critical for peptides, which are unstable at high temperatures and often require strict control over particle properties.
The new spray drying suite operates as a closed-loop system, equipped with its own inert gas supply and advanced safety measures, including specialized HVAC, airlocked entries and exits, operator isolation, and a dedicated cleaning area. This enables the safe handling of potent compounds and organic solvents requiring up to Band 5 containment. To further strengthen these capabilities, the processing area maintains ISO Class 8 (Class 100,000) cleanliness standards, ensuring strict control of the environment throughout operations.
"Peptides present some of the most intricate formulation challenges in pharmaceutical development, owing to their inherent instability and sensitivity to processing conditions," said Dr. Jordi Bacardit, global technical lead on peptides and member of the science collective at PPS. "Spray drying addresses these distinct challenges by allowing tight control over key components like temperature and solvent environment. With the addition of the spray drying suite at Turbhe, we can help our partners bring stable, high-quality peptide formulations to patients in need worldwide."
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