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Pin Therapeutics, a clinical-stage biotechnology company, announced that it has administered the first dose of its CK1a-selective degrader PIN-5018 in a phase 1 clinical trial. The first patient enrolled has adenoid cystic carcinoma (ACC), a rare malignancy with limited treatment options.
PIN-5018 is an oral CK1a degrader developed based on the novel hypothesis of "synthetic activation of p53." The company is evaluating PIN-5018 as both a monotherapy and in multiple combination regimens. The phase 1 study employs a dose-escalation design to assess safety, pharmacokinetics (PK), and target engagement/pharmacodynamics (PD). Pin Therapeutics also plans to expand development into additional indications.
- PIN-5018 achieves complete response in ACC PDX models
The company highlighted compelling preclinical data in ACC, a disease with no approved standard-of-care therapy. In two patient-derived xenograft (PDX) models, treatment with PIN-5018 resulted in a complete response (CR) in one model and marked tumour regression in the other, demonstrating robust antitumor activity and supporting clinical translation.
- Expansion planned into mCRPC, colorectal cancer, and other rare tumours
Pin Therapeutics notes that CK1a plays a key biological role in resistance mechanisms that emerge during androgen receptor (AR) inhibitor therapy. Based on this insight, the company is pursuing a strategy aimed at enabling rapid entry into the first-line (1L) setting for metastatic castration-resistant prostate cancer (mCRPC) through combination therapy with an AR signalling inhibitor (ARSI). In colorectal cancer, the company is advancing a clinical program based on the innovative concept of "synthetic activation of WNT signalling."
- Advancing mechanism-based precision oncology
Pin Therapeutics emphasized its commitment to mechanism-based precision oncology across its entire pipeline by applying sophisticated biological mechanisms. Ongoing initiatives include mode-of-action studies, integrated PK/PD analysis, and biomarker development to identify the most appropriate patient populations for each indication.
"Our goal is to leverage our innovative degradation modality and novel biological frameworks to provide meaningful therapeutic options for cancer patients with limited or no existing treatments," Pin Therapeutics CEO Hyunsun Jo said. "We look forward to demonstrating the clinical value of PIN-5018 across multiple tumour types."
Pin Therapeutics is a biotech company in Targeted Protein Degradation (TPD) field and located in South Korea and SF Bay area. With the experts in various parts of new drug discovery, Pin is developing novel platforms and screening systems called “PinE3” (for novel E3 ligases) and “PinGLUE” (for novel Molecular Glue Degraders) to address the limitations of current TPD technology and develop promising pipelines targeting specific medical unmet needs in the field.
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