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ICMR announces intramural grant recipients for 35 selected cutting-edge research projects

Shardul Nautiyal, Mumbai
Tuesday, August 20, 2024, 08:00 Hrs  [IST]

The Indian Council of Medical Research (ICMR) has announced the recipients of the prestigious Intramural Ignition Grants. Thirty-five groundbreaking research projects across various health disciplines have been selected for funding. These projects aim to address significant healthcare challenges in India and enhance the scientific understanding of a wide range of diseases.

The Ignition Grant programme, which closed for applications on January 31, 2024, aims to support early-stage and innovative research with a focus on translational impact. The selected projects are subject to final approval based on the completion of technical, budgetary, and ethical requirements.

Selected projects include non-human primate model for neurological disorders. This study aims to develop a non-human primate model using non-invasive electroencephalography (EEG) to better understand neurological disorders, which could pave the way for new diagnostic and therapeutic approaches.

In the area of AI-driven algorithm to combat drug resistance in tuberculosis, the development of an artificial intelligence-driven pharmacokinetics algorithm is expected to improve the management of drug-resistant tuberculosis, a growing public health challenge in India.

In trauma care enhancement at health and wellness centers, this implementation research aims to improve trauma care at India's Health and Wellness Centers, focusing on operationalizing protocols that can save lives in critical situations.

The dengue and chikungunya surveillance will target hotspot regions in India, this project seeks to enhance the integrated surveillance system for dengue and chikungunya, utilizing epidemiological and entomological data to prevent outbreaks.

A CRISPR/Cas-based lateral flow assay diagnostic test is being developed to detect Mycoplasma pulmonis, representing a significant step forward in rapid and accurate disease detection.

The 3D tumor model for drug-resistant leukemia project focuses on creating a 3D tumor model to study the effectiveness of therapies targeting immunogenic cell death and angiogenesis in drug-resistant T-cell acute lymphoblastic leukaemia (T-ALL).

In the area of evaluating the impact of nicotine and stress on atherosclerosis, a model will be used to study the molecular and biomarker features of atherosclerosis, exploring the impact of nicotine and stress on the disease’s progression.

The micronutrient levels and gestational diabetes longitudinal study will track micronutrient levels and their relationship to gestational diabetes mellitus from preconception to delivery, providing insights into maternal and child health.

The selected projects will be funded subject to the following conditions: Satisfactory responses to technical and budgetary comments, timely completion of all formalities, including the submission of ethics approval within three months of selection notification, no spending on project activities until the final approval and release of funds by the ICMR, diverse and impactful projects.

The selected research proposals cover a wide spectrum of medical and public health challenges, including non-communicable diseases (NCDs). Several projects focus on NCDs, including studies on multimorbidity, cardiovascular disease, and cancer. Infectious diseases: Research addressing tuberculosis, malaria, and dengue aims to improve diagnostics, treatment, and disease control strategies. Machine learning and AI: Advanced technology-driven projects, such as machine learning for sickle cell disease complications and AI-based tuberculosis management, demonstrate the increasing role of AI in healthcare innovation.

Notable Public Health Projects include Elderly Care and Frailty Management. This project aims to develop and implement a frailty management model for elderly people living in the community, potentially improving quality of life and reducing healthcare costs.

In nutrition and malnutrition, this study will assess the impact of nutritional interventions on micronutrient status among under-five children in tribal regions, focusing on addressing severe acute malnutrition.

In traditional medicine, researchers will develop and validate a tool to assess patient perceptions of traditional and non-codified medical practices, contributing to the integration of these practices into mainstream healthcare.

The ICMR’s Ignition Grant programme continues to be a critical platform for fostering innovative research with the potential to make a significant impact on public health and clinical practice in India. The selected projects will not only enhance the understanding of various health conditions but also offer solutions that can be translated into real-world applications, benefitting millions of people.

 

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