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Researchers find positive results to develop thermo stable insulin which could be stored at room temperatures

A Raju, Hyderabad
Monday, October 11, 2021, 08:00 Hrs  [IST]

A collaborative research by scientists from Hyderabad and Kolkata has found out the possibility of manufacturing thermo stable injectable dose of insulin, which could be easily stored at room temperatures.

A study, led by team of researchers from Council of Scientific and industrial Research-Indian Institute of Chemical Technology (CSIR-IICT) Hyderabad and Indian Institute of Chemical Biology Kolkata, has found positive results to develop thermo stable insulin, which could be stored at room temperatures and can be carried anywhere by the diabetic patients during traveling without having the need to store the medicine at a cool temperature.

According to Dr Jitender Reddy, a scientists from NMR centre of CSIR-IICT, Hyderabad a collaborative study was taken up to develop injectable thermo-stable insulin that can be stored at room temperatures, which could address the difficulties in cold-chain management of insulin and also attract the attention of pharmaceutical companies involved in the developing thermo-stable insulin.

As part of their research the scientists have shown that a small peptide molecule consisting of four amino acids named ‘Insulock’ prevents both heat and storage induced insulin fibrillation (freezing) and thereby loss of effective quantum of insulin.

The researchers have found that the ‘Insulock’ is non-toxic, non immunogenic and heat stable and can maintain insulin in the active form at room temperatures even for long periods up to many months. “The ‘Insulock’ has been evaluated in mice models and has yielded good results. Getting the structural insights about the Insulock and establishing its 3D structural similarity with respect to the native insulin Injectable solution are key steps. These things are achieved at our NMR centre at IICT Hyderabad,” informed Dr. Jitender Reddy.

Highlighting the contributions of various scientists, it is informed that the research to develop thermo-stable insulin consisted of identification of an appropriate small peptide to inhibit the insulin from fibrillation, which was accomplished by Dr. Subrangsu Chatterjee, Associate professor of Bose Institute and Dr Partha Chakrabarti, Principal investigator.

The determination of the 3-D structure of the Insulock-insulin complex and its thermal stability by using high resolution nuclear magnetic resonance (NMR) spectroscopy was accomplished by Dr. B Jitender Reddy.

For diabetic patients it is often required to make sure to maintain cold temperatures between 2-8 degrees Celsius to store the injectable insulin. But now the new research study has developed new methods and processes to manufacture injectable insulin that can be stored at room temperatures and now the diabetic patients can avoid the often difficult task of maintaining low temperatures.

Particularly for the patients living in remote areas, it is very difficult to keep injectable insulin in refrigerators. There are occasions when patients use ice to maintain the temperatures while storing insulin, however, on such occasions, there is always at chance of insulin getting frozen and not fit for use. The problem is seen more among those diabetic patients who often travel and cannot maintain such cold chain safety precautions of storing insulin.

 

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